BACKGROUND: Some maternal characteristics indicate worse prognosis in pregnancies with COVID-19 .
OBJECTIVE: Describe prevalence of endocrine disorders in pregnancies with COVID-19, and impact on maternal outcomes . SEARCH STRATEGY: 'pregnancy' and 'COVID-19' . SELECTION: PubMed, Embase, medRxiv and Cochrane worksheet; from February to July 2020 . DATA COLLECTION AND ANALYSIS: articles describing endocrine disorder in pregnancies with and without COVID-19; we performed meta-analyses of prevalence using random-effect models and estimated relative risk and 95% CI of maternal outcomes relative to presence of endocrine disorders . MAIN
RESULTS: Articles included (n=141) were divided in three datasets: individual (119 articles , 356 women), case series (17 articles , 1064 women) and national registries (7 articles , 10 178 women). Prevalence of obesity ranged from 16% to 46; hyperglycemia in pregnancy (HIP), from 8% to 12% . In dataset 1, HIP and obesity were risk factors for severe disease in crude and age adjusted models, although not for intensive care unit admission . In data from two national registries, risk of dying was 5.62 (95% CI 0.30-105.95) in women with diabetes and 2.26 (95% CI 1.03-4.96) in those with obesity .
CONCLUSION: Obesity and HIP were prevalent in pregnancies with severe COVID-19.