Objective: To investigate both muscular manifestations and CK levels in a large cohort of patients with COVID-19 infection and to determine whether hyperckemia is associated with morbidity and mortality .
Methods: Data of 615 patients discharged from ASST Ovest Milanese (Milan, Lombardy, Italy) with final diagnosis of COVID-19 infection were retrospectively extracted from electronical medical records from 21 February to 1 May 2020 . Patients were descriptively analyzed with respect to the following variables: sex, age, muscular manifestations (myalgia and/or arthralgia), fatigue, respiratory involvement (SARS pneumonia or respiratory failure) and history of falls . Association between patients' characteristics and CK levels was investigated . In addition, the proportion of patients who died following access to the ER was calculated . Finally, the effect of CK levels and other patients' features on mortality was estimated using a logistic regression model . Results : 176 (28.6 %) patients had raised serum CK levels . CK levels were significantly associated with history of falls, male gender, SARS pneumonia, respiratory failure and in-hospital death . No correlation was found between hyperckemia and muscular manifestations .
Conclusions: Our study provides preliminary evidence that hyperckemia is associated with respiratory failure and fatal outcome in patients with COVID-19 infection.In these patients, among other testing, CK dosage is recommended.