The COVID-19 pandemic has revealed a ventilator deficit in the global health system for this scenario . For this reason, several national and international projects have been developed to get done prototypes of ventilators which could be easy and fast to manufacture . One of the requirements of the AEMPS for conducting clinical studies with new prototypes is through the validation of these new prototypes in an animal model . Therefore, it is important to achieve an animal model which allows us to easily reproduce different clinical scenarios . In this article, we describe the use of a sheep as a research model to assess a prototype ventilator . The animal was anesthetized for 10hours in which the prototype was tested in up to 6different scenarios . This model is effective and easy to reproduce, making it an excellent choice for this kind of research.