A 61-year-old man was transferred to our facility from an outside hospital due to refractory neutropaenia of unknown aetiology . The patient presented to the referring hospital with a 5-day history of worsening diarrhoea and abdominal pain . Initial lab results at presentation showed severe neutropaenia with an absolute neutrophil count of 0 . Investigations included a bone marrow biopsy which showed slightly hypocellular marrow with near absence of granulocytic precursors . A CT without contrast showed evidence of chronic pancreatitis and acute colitis . The patient's neutropaenia persisted despite granulocyte colony-stimulating factor therapy . The patient was, thus, transferred to our facility for a higher level of care . At our facility, the patient had rapid correction of neutropaenia after discontinuation of pancrelipase therapy . The patient's abdominal pain and diarrhoea also improved while off pancrelipase . Neutropaenia has completely resolved 6 weeks after discharge without any further therapy.