Expansion of COVID-19 worldwide increases interest in unraveling genomic variations of novel SARS-CoV-2 virus . Metadata of 408,493 SARS-CoV-2 genomes submitted to GISAID database were analyzed with respect to genomic clades and their geographic, age, and gender distributions . Of the currently known SARS-CoV-2 clades, clade GR was the most prevalent worldwide followed by GV then GH . Chronological analysis revealed expansion in SARS-CoV-2 clades carrying D614G mutations with the predominance of the newest clade, GV, in the last three months . D614G clades prevail in countries with more COVID-19 cases . Of them, the clades GH and GR were more frequently recovered from severe or deceased COVID-19 cases . In contrast, G and GV clades showed a significantly higher prevalence among asymptomatic patients or those with mild disease . Metadata analysis showed higher (p <0.05) prevalence of severe/deceased cases among males than females and predominance of GR clade in female patients . Furthermore, severe disease/death was more prevalent (p <0.05) in elderly than in adults/children . Higher prevalence of the GV clade in children compared to other age groups was also evident . These findings uniquely provide a statistical evidence on the adaptation-driven evolution of SARS-CoV-2 leading to altered infectivity, virulence, and mortality.