Introduction: Obesity and higher BMI is one of the leading comorbidities to increase the risk of COVID-19 severity . This paper presents a systematic review and meta-analysis estimating the effects of overweight and obesity on COVID-19 disease severity .
Method: ology: Two electronic databases (Medline and Cochrane library) and one grey literature database (Grey Literature Report) were searched . The risks of bias of the selected studies were assessed by using the Navigation Guide method for human data . Both random and fixed effect meta-analyses were determined using Review Manager (RevMan) software version 5.4 .
Results: After initial screening , 12 studies were fulfilled the eligibility criteria, comprising a total of 405359 patients, and included in the systematic review . The pooled risk of COVID-19 severity was 1.31 times higher based on both fixed and random effect model among those overweight patients, I 2 0% and 2.09 and 2.41 times higher based on fixed and random effect respectively among obese patients, I 2 42% compared to healthy individuals . Conclusion: Overweight and obesity are found to be risk factors for disease severity of COVID-19 patients . However, further assessment of metabolic parameters is required to estimate the risk factors of COVID-19 patients and understanding the mechanism between COVID-19 and body mass index.