OBJECTIVE: The aim of the COVER Study is to identify global outcomes and decision making for vascular procedures during the pandemic .
BACKGROUND DATA: During its initial peak, there were many reports of delays to vital surgery and the release of several guidelines advising later thresholds for vascular surgical intervention for key conditions .
METHODS: An international multi-center observational study of outcomes after open and endovascular interventions .
RESULTS: In an analysis of 1103 vascular intervention (57 centers in 19 countries), 71.6% were elective or scheduled procedures . Mean age was 67â±â14 years (75.6% male). Suspected or confirmed COVID-19 infection was documented in 4.0% . Overall, in-hospital mortality was 11.0% [aortic interventions mortality 15.2% (23/151), amputations 12.1% (28/232), carotid interventions 10.7% (11/103), lower limb revascularisations 9.8% (51/521) ]. Chronic obstructive pulmonary disease [odds ratio (OR) 2.02 , 95% confidence interval (CI) 1.30-3.15] and active lower respiratory tract infection due to any cause (OR 24.94 , 95% CI 12.57-241.70) ware associated with mortality, whereas elective or scheduled cases were lower risk (OR 0.4 , 95% CI 0.22-0.73 and 0.60 , 95% CI 0.45-0.98, respectively . After adjustment, antiplatelet (OR 0.503 , 95% CI : 0.273-0.928) and oral anticoagulation (OR 0.411 , 95% CI : 0.205-0.824) were linked to reduced risk of in-hospital mortality .
CONCLUSIONS: Mortality after vascular interventions during this period was unexpectedly high . Suspected or confirmed COVID-19 cases were uncommon . Therefore an alternative cause, for example, recommendations for delayed surgery, should be considered . The vascular community must anticipate longer term implications for survival.