Introduction: Covid-19 vaccines can cause adverse events (AE) that can lead to increased hesitation or fear of vaccination . This study aims at estimating the prevalence of severe adverse events (SAEs) and their associated factors among health professionals (HPs) vaccinated with COVISHIELD (TM) vaccine in Togo .
Methods: A cross-sectional study was conducted from March 13th to 19th , 2021 in Togo among HPs who received the first dose of vaccine . An online self-administered questionnaire was used to collect data on sociodemographic characteristics and vaccination . SAEs were defined as one resulting in hospitalization, medical consultation, or inability to work the day following the administration of the vaccine . Regression analysis were performed to assess factors associated with SAEs .
Results: A total of 1,639 HP (70.2% male) with a median age [IQR] of 32 years [27-40] participated . At least one AE was reported among 71.6% (95% CI= [69.3-73.8] ). The most commonly reported AEs were pain at the injection site (91.0 %), asthenia (74.3 %), headache (68.7 %), soreness (55.0 %), and fever (47.5 %). An increased libido was also reported in 3.0% of HP . Among HP who experienced AEs , 18.2% were unable to go to work the day after vaccination , 10.5% consulted a medical doctor, and 1.0% were hospitalized . The SAE prevalence was 23.8% (95% CI= [21.8-25.9] ). Being <30 years (aOR=5.54; p <0.001), or 30-49 years (aOR=3.62; p <0.001) and being female (aOR=1.97; p <0.001) were associated with SAEs . Conclusion: Despite the occurrence of SAEs, current data collected in Togo about adverse events are reassuring with COVISHIELD (TM) vaccine and how they could be managed . Keywords: Severe adverse event, COVID-19, vaccine, prevalence, health professionals, Togo.