BACKGROUND Fast identification of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) infected individuals is a strategically vital task to ensure correct management and quarantine . Rapid antigen test could be a supplement to the standard-of-care Nucleic Acid Amplification Test (NAAT). The aim of this study was to determine the accuracy of the BD Veritor SARS-CoV-2 antigen test as a screening instrument in a hospital setting .
METHODS A cohort of prospective samples were collected from hospital staff and patients at the Emergency, Infectious Diseases and Pediatrics and Adolescent Medicine departments at Hvidovre Hospital . All samples were collected using oropharyngeal swabs, and BD Veritor Antigen test results were paired with routine NAAT test results . Sensitivity, specificity, positive and negative predictive values of the antigen test were calculated using NAAT as reference .
RESULTS Overall , 809 samples from 674 individuals were included (average age 45 years, range 0-98 years). Among all samples , 8% were SARS-CoV-2 positive by NAAT testing and 5.3% by BD Veritor . The sensitivity of the antigen test was 63.1% and specificity 99.7% . The positive predictive value was 95.3% . False-positive rate was 4% . The cycle threshold value was significantly higher among individuals with false negative antigen tests compared to true positives .
CONCLUSION The sensitivity, specificity and positive predictive values show that the BD Veritor antigen test from oropharyngeal collected specimens performs well . Antigen testing may be a supplement, but not substitute, to NAAT testing as the primary diagnostic modality in hospital settings where fast turnaround test results may assist in decisions regarding isolation and quarantine.