This chapter presents the usage of data science, which further helps in exploring the global pandemic COVID-19. This disease suppresses an overwhelming burden, not only to healthcare systems but to the world's economy too. In this era of techniques and technologies, it is believed that data science can better utilize scarce healthcare resources. In this chapter, we provide an introduction of data science and its applications, which helps in combating different aspects of COVID-19. Publicly available datasets related to disease are used as community resources. Different kinds of datasets are used to analyze various aspects of pandemic at different scales. These different kinds of datasets can be audio, video, textual, speech, and sensor data. More than hundreds of research articles are also studied to prepare a bibliometric study. Apart from grabbing all the advantages from datasets, this paper highlights a few challenges, such as surety of correct data, need of multidisciplinary collaboration, new data modality, security issues, and availability of data.